据《美国心脏病学会杂志》报道，心脏病发作后第一年内，用β-受体阻断剂类药物进行治疗，并未增加患者的抑郁风险。内科医生不必再犹豫让心脏病患者服用β-受体阻断剂。
荷兰Groningen 大学医学中心的Joost P. van Melle博士说，在美国一些常用的β-受体阻断剂包括Inderal、Lopressor、Toprol XL。Van Meller和他的同事们注意到，β-阻断剂能够降低心脏病患者23％的死亡率，该药物还可用于治疗高血压、心绞痛、偏头痛和其他不适等。但是，人们一直担心β-受体阻断剂在神经、心理等方面的副作用。
研究人员调查了381名患者心脏病发病后一年内服用β-阻断剂与抑郁之间的关系。结果发现，在心脏病发作后3个月、6个月、12个月时，服用β-阻断剂的患者和未服用β-阻断剂患者的BDI得分无明显差异。这表明患者心脏病发作后一年内服用β-阻断剂与不服用β-阻断剂相比患抑郁症的风险未增加。
在服用β-阻断剂患者中，服用不同剂型的β-阻断剂，即水溶性或者脂溶性，其结果没有差别。
van Melle 和他的同事说：“尽管目前认为β-受体阻断剂有潜在（致抑郁的）副作用，但是我们没有发现心脏病患者短期可能发生抑郁的证据。
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然而，在6个月和12个月时，研究人员观察到，服用高剂量β-阻断剂的患者比服用低剂量患者的BDI得分明显升高，表明其抑郁水平更低。“将有更多的研究来探索长期和高剂量的β-阻断剂对抑郁症状的影响，”研究人员总结说。
Beta-blockers don't increase depression risk
Reuters Health
Wednesday, December 6, 2006
By Will Boggs, MD
NEW YORK (Reuters Health) - Treatment with a class of drugs called beta-blockers do not appear to increase a patient's risk of depression in the first year after a heart attack, according to a report in the Journal of the American College of Cardiology.
Physicians do not have to be hesitate in prescribing beta-blockers in heart attack patients anymore, Dr. Joost P. van Melle from University Medical Center Groningen, the Netherlands, told Reuters Health. Some common beta-blocker trade names used in the U.S. include Inderal, Lopressor and Toprol XL.
van Meller and his colleagues note that beta-blockers have reduced mortality in heart patients by 23 percent. These drugs are also used to treat high blood pressure, angina, migraine and other disorders. However, concerns about neurological, psychological and other side effects persist.
The researchers investigated the association between beta-blocker use and depression in the first 12 months after heart attack 381 patients.
The team found that Beck Depression Inventory Scores at 3, 6, and 12 months post-heart attack did not differ significantly in patients taking beta-blockers and patients not taking beta-blockers. The results indicate that patients taking beta-blockers were no more likely to be diagnosed with depressive disorder during the year after their heart attack than those not taking beta-blockers.
Among patients taking beta-blockers, outcomes did not differ by type of beta-blocker they received -- a hydrophilic beta-blocker or a lipophilic beta-blocker.
"Despite current beliefs about the potential side effects of beta-blockade," van Melle and colleagues write, "we found no support for short-term effects on prospective depression in an (heart attack) population."
However, at 6 and 12 months, the researchers note, patients taking high-dose beta-blockers had significantly higher scores on the Beck Depression Inventory test (indicating lower depression levels) than did patients taking low-dose beta-blockers.
"More research is warranted to explore the long-term and high-dose effects of beta-blockers on depressive (symptoms)," the investigators conclude.
SOURCE: Journal of the American College of Cardiology, December 5, 2006.
http://www.nlm.nih.gov/medlineplus/news/fullstory_42241.html
编辑：蓝色幻想
