Int J Cardiol 2011 Nov;153 (1): 14-20. [IF:6.802]
n-3 polyunsaturated fatty acids prevents atrial fibrillation by inhibiting inflammation in a canine sterile pericarditis model.
Zhang Z , Zhang C , Wang H , Zhao J , Liu L , Lee J , He Y , Zheng Q .
Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Baqiao District, Xi'an 710038, PR China.
西安第四军医大学唐都医院心内科
Abstract
It has been recently reported that atrial fibrillation (AF) is associated with inflammation and inflammatory cytokines, and n-3 polyunsaturated fatty acids (PUFAs) might be of anti-inflammatory effects. This study was to evaluate the anti-inflammatory effect of PUFAs on AF in a canine sterile pericarditis model. 20 dogs were randomly assigned to two groups: control group (10 dogs) and PUFA treatment group (10 dogs), in which sterile pericarditis was created by open-chest operation. PUFAs were administered orally (2g/day) 4weeks before the operation till the end of the study. Before and 2days after the operation, CRP, IL-6, TNF-α levels, the inducibility and maintenance of AF, the atrial effective refractory period (AERPs), and intra-atrial conduction time were determined. Before the operation, there were no significant differences in any of the parameters between the two groups. On the second postoperative day, the PUFA group had a lower CRP level (7.6±0.5 vs. 11.7±1.3mg/dl, P<0.0001), a lower IL-6 level (112.0±37.3 vs. 142.0±19.6pg/ml, P<0.01), a lower TNF-α level (83.3±8.5 vs. 112.4±8.2pg/ml, P<0.0001), a less AF inducibility (percentage of burst attempts leading to AF episodes: 11±7.4 vs. 28±10.3, P<0.001) and maintenance [median AF duration: 1105s (655.8-1406.5) vs. 2516.5s (1187-3361), P<0.05], a longer AERP (133.4±4.1 vs. 129.8±4.3ms, P<0.05), and a shorter intra-atrial conduction time (46.6±4.4 vs. 51.9±4.8ms, P<0.05) than the control group. Dietary n-3 PUFA supplementation attenuates the inducibility and maintenance of AF in the sterile pericarditis model by reducing the production of proinflammatory cytokines.
摘要：
最近发表的文章说房颤与炎症和炎性的细胞活素类相关联，并且n-3多不饱和脂肪酸（多不饱和脂肪酸）可能起到抗炎作用。这个研究在一个无菌犬心包炎模型上评估了多不饱和脂肪酸在房颤上的抗炎效果。20只狗被随机分配到两组：对照组（10只狗）和多不饱和脂肪酸处理组(10只狗)，在这里无菌的心包炎用开胸术制造。在手术前给予多不饱和脂肪酸（2g/天）4周直到研究结束。在手术之前和手术结束后2天，受体蛋白，白细胞介素-6，肿瘤坏死因子-a水平，决定了诱发和维持房颤，心房有效不应期，和房内传导时间。在手术之前，两组中的任何因素都没有显著性差异，在术后第2天，多不饱和脂肪酸组和对照组相比出现受体蛋白低水平，(7.6±0.5 比11.7±1.3mg/dl, P<0.0001),白介素-6低水平 (112.0±37.3 比 142.0±19.6pg/ml,P<0.01), 肿瘤坏死因子-α低水平(83.3±8.5 比 112.4±8.2pg/ml,P<0.0001),一个低水平的诱发房颤（导致房颤发作尝试的百分比：11±7.4 比28±10.3, P<0.001）和维持（房颤的中段1105秒 (655.8-1406.5)比2516.5秒 (1187-3361), P<0.05），一个更长的心房有效不应期，(133.4±4.1比 129.8±4.3毫秒, P<0.05), 和一个更短的房内传导时间 (46.6±4.4 比 51.9±4.8毫秒, P<0.05).饮食中 n-3多不饱和脂肪酸的增补通过减少促炎症反应的细胞活素的产生减弱了在无菌的心包炎模型中诱发和维持房颤。
