在过去的二十到三十年间，果糖的摄入和肥胖的流行都在增长。与葡萄糖相比，果糖在肝中进行促脂肪生成的代谢，可导致高血脂和肥胖。果糖并不增加胰岛素和瘦素（leptin）的水平，也不降低多肽饥饿激素（ghrelin）的水平，暗示了这样一种内分泌机制，它可以导致确实的能量平衡。这个综述验证了果糖对能量稳态和糖脂代谢的作用的有效数据。新近的出版物、人类课题的研究以及需要补充研究的领域里都有强调。
Reference:
Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism.
Nutr Rev. 2005 May;63(5):133-57.
Fructose intake and the prevalence of obesity have both increased over the past two to three decades. Compared with glucose, the hepatic metabolism of fructose favors lipogenesis, which may contribute to hyperlipidemia and obesity. Fructose does not increase insulin and leptin or suppress ghrelin, which suggests an endocrine mechanism by which it induces a positive energy balance. This review examines the available data on the effects of dietary fructose on energy homeostasis and lipid/carbohydrate metabolism. Recent publications, studies in human subjects, and areas in which additional research is needed are emphasized.
