Thymus changes in anti-MuSK-positive and -negative myasthenia gravis.
Lauriola L, Ranelletti F, Maggiano N, Guerriero M, Punzi C, Marsili F, Bartoccioni E, Evoli A.
Morphologic findings of thymuses from 32 anti-acetylcholine receptor (AChR)-negative myasthenia gravis patients, 12 with and 20 without antibodies against the muscle-specific kinase (MuSK), were compared with those from 30 AChR-positive subjects. In contrast with the high frequency of thymic hyperplastic changes in AChR-positive patients, in MuSK-positive subjects histologic alterations were minimal, arguing against an intrathymic disease pathogenesis. Since hyperplastic changes were seen in 35% of MuSK-negative patients, the thymus could be involved in some of these cases.
MuSK抗体阳性和阴性MG病人中的胸腺改变
Lauriola等研究了32名乙酰胆碱受体抗体阴性的胸腺形态学变化，其中有12例肌肉特异性激酶（MuSK）抗体阳性，20例阴性；对照组为30例乙酰胆碱受体抗体阳性的病人。与乙酰胆碱受体抗体阳性病人的胸腺增生改变不同，MuSK抗体阳性MG病人的胸腺病理学改变较轻，此结果不太支持该类病人的胸腺内致病机制。然而在35%的MuSK抗体阴性的病人中可见明显胸腺增生，提示胸腺在此类病人的致病机制中有一定的作用。
