Ulug AM, Grunewald T, Lin MT, Kamal AK, Filippi CG, Zimmerman RD, Beal MF.
PURPOSE: To evaluate the utility of MR diffusion tensor imaging in diagnosing primary lateral sclerosis (PLS). MATERIALS AND METHODS: Five patients who met clinical criteria for a diagnosis of PLS, and two patients with possible PLS of less than three years duration and eight normal volunteers were studied using MR diffusion tensor imaging. RESULTS: All seven patients showed decreased diffusion anisotropy and increased diffusion constant in the PLIC, with complete separation from a normal control group, including patients early in the course of the illness. CONCLUSION: Quantitative diffusion tensor imaging appears to be a useful test to detect upper motor neuron damage and hence to help to establish the diagnosis of PLS.
弥散张力呈像在原发性侧索硬化中的作用
Ulug等分析了弥散张力磁共振在7名原发性侧索硬化（PLS）病人和8名健康志愿者中的表现，PLS中有5名符合临床诊断标准，2名为可能的PLS，病程小于3年。所有PLS病人表现为弥散各向异性减少，而PLIC的弥散常数则增加，与正常对照截然不同。结果表明定量弥散张力MR是检测上运动神经元损害的有用手段，对确诊PLS有益。
J Magn Reson Imaging. 2004 Jan;19(1):34-9.
