Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Tanabe Y, Fujimoto S, Matsuishi T.
Based on the hypothesis that mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS) are caused by impaired vasodilation in an intracerebral artery, the authors evaluated the effects of administering l-arginine, a nitric oxide precursor. Patients were administered L-arginine intravenously at the acute phase or orally at the interictal phase. L-arginine infusions significantly improved all strokelike symptoms, suggesting that oral administration within 30 minutes of a stroke significantly decreased frequency and severity of strokelike episodes.
有假说认为MELAS是由颈内动脉系统血管舒张障碍所致。Koga等评估了L-精氨酸在此类疾病中的疗效，左旋精氨酸是一种一氧化氮的前体物质，病人于急性期接受左旋精氨酸的静脉治疗或于发作间期接受口服治疗，结果发现左旋精氨酸静脉输注可明显改善卒中样症状，而在卒中开始头30分钟内口服左旋精氨酸明显减少卒中样发作的频率和严重性。
Neurology. 2005 Feb 22;64(4):710-2.
